The 2022 NFL schedule has finally arrived, and Caesars Sportsbook has released the latest point totals and spreads for all of the Week 1 games. Bettors will have plenty of time to make calls on which games from the Week 1 slate are the most intriguing.
The defending Super Bowl champion Los Angeles Rams welcome Josh Allen and the Buffalo Bills to SoFi Stadium to kick the season off on Sept. 8. And new Denver Broncos QB Russell Wilson returns to Seattle to face the Seahawks at Lumen Field.
Check out the latest NFL odds below.
All odds are courtesy of Caesars Sportsbook.
Week 1 Lines
Buffalo Bills at Los Angeles Rams
Thursday, 8:20 p.m. ET, SoFi Stadium, Inglewood, California
Line: Rams (-1)
Money line: Rams (-120), Bills (+100)
Over/Under: 52.5 points
San Francisco 49ers at Chicago Bears
Sunday, 1:05 p.m ET, Soldier Field, Chicago
Line: 49ers (-6)
Money line: 49ers (-270), Bears (+220)
Over/Under: 43 points
New England Patriots at Miami Dolphins
Sunday, 1:05 p.m ET, Hard Rock Stadium, Miami Gardens, Florida
Line: Dolphins (-3)
Money line: Dolphins (-150), Patriots (+130)
Over/Under: 44.5 points
New Orleans Saints at Atlanta Falcons
Sunday, 1:05 p.m ET, Mercedes-Benz Stadium, Atlanta
Line: Saints (-3)
Money line: Saints (-170), Falcons (+145)
Over/Under: 42.5 points
Baltimore Ravens at New York Jets
Sunday, 1:05 p.m ET, MetLife Stadium, East Rutherford, New Jersey
Line: Ravens (-4)
Money line: Ravens (-190), Jets (+160)
Over/Under: 45.5 points
Pittsburgh Steelers at Cincinnati Bengals
Sunday, 1:05 p.m ET, Paul Brown Stadium, Cincinnati
Line: Bengals (-6)
Money line: Bengals (-270), Steelers (+220)
Over/Under: 44 points
Cleveland Browns at Carolina Panthers
Sunday, 1:05 p.m ET, Bank of America Stadium, Charlotte, North Carolina
Line: Browns (-4.5)
Money line: Browns (-200), Panthers (+170)
Over/Under: 43.5 points
Philadelphia Eagles at Detroit Lions
Sunday, 1:05 p.m ET, Ford Field, Detroit
Line: Eagles (-3.5)
Money line: Eagles (-200), Lions (+170)
Over/Under: 47 points
Indianapolis Colts at Houston Texans
Sunday, 1:05 p.m ET, NRG Stadium, Houston
Line: Colts (-7.5)
Money line: Colts (-380), Texans (+300)
Over/Under: 45 points
Jacksonville Jaguars at Washington Commanders
Sunday, 1:05 p.m ET, FedEx Field, Landover, Maryland
Line: Commanders (-4.5)
Money line: Commanders (-210), Jaguars (-175)
Over/Under: 58.5 points
Kansas City Chiefs at Arizona Cardinals
Sunday, 4:25 p.m ET, State Farm Stadium, Glendale, Arizona
Line: Chiefs (-3)
Money line: Chiefs (-160), Cardinals (+140)
Over/Under: 55 points
Green Bay Packers at Minnesota Vikings
Sunday, 4:25 p.m ET, U.S. Bank Stadium, Minneapolis
Line: Packers (-1.5)
Money line: Packers (-125), Vikings (+105)
Over/Under: 48.0 points
Los Angeles Chargers at Las Vegas Raiders
Sunday, 4:25 p.m ET, Allegiant Stadium, Paradise, Nevada
Line: Chargers (-4)
Money line: Chargers (-190), Raiders (+160)
Over/Under: 51.5 points
New York Giants at Tennessee Titans
Sunday, 4:25 p.m ET, Nissan Stadium, Nashville, Tennessee
Line: Titans (-6.5)
Money line: Titans (-300), Giants (+240)
Over/Under: 44 points
Tampa Bay Buccaneers at Dallas Cowboys
Sunday, 8:30 p.m ET, At&T Stadium, Arlington, Texas
Line: Buccaneers (-2.5)
Money line: Buccaneers (-135), Cowboys (+115)
Over/Under: 52 points
Denver Broncos at Seattle Seahawks
Monday, 7:30 p.m ET, Lumen Field, Seattle
Line: Broncos (-3.5)
Money line: Broncos (-180), Seahawks (+155)
Over/Under: 41.5 points